赵喆
特聘研究员
院系:WilliamHill生物医学工程与诊断药学系
招生方向:生物医学工程
实验室:中国药科大江北创新中心E11楼
电子邮箱:zhaozhe@cpu.edu.cn
办公室:中国药科大江北创新中心E11楼
个人简介

威廉希尔特聘研究员、博士生导师。2020年博士毕业于苏州大学,2020-2026年于中国科公司苏州纳米所从事博士后工作。2026年至今于威廉希尔,WilliamHill,生物医学工程与诊断药学系开展独立研究工作,主要从事肿瘤类器官标准化构建新技术开发与肿瘤干细胞筛选等。迄今为止在Nature Cell Biology、MedComm等国际知名学术期刊发表多篇论文,获授权并转化专利3项。主持国家、江苏省自然科学基金青年基金等项目多项。

研究方向

肿瘤类器官标准化构建新技术开发

肿瘤干细胞筛选

承担项目情况

主持国家自然科学基金青年基金、江苏省自然科学基金青年基金、苏州市政策性资助项目等

代表性科研成果

(1)Zhao Z, Wang J, Xiong X, Zhang S, Suo G#, et al. High-throughput generation of patient-derived cancer stem cells for precision medicine using microwell-chip platform. Nature Cell Biology 2026; 10.1038/s41556-026-01957-1

(2)Wu H, Zhao Z, Zhang L, Xiong X, Yang M, Ge W, Zhi D, Cao X, Yi C, Qiao Y, Cao J, Mei Y, Jiao S, Liu Q, Zhou H, Xu Z, Suo G. Bispecific NK-Cell Engager Targeting TP53 Mutation Through Integration of a TCR-mimic Antibody. MedComm (2020). 2026;10.1002/mco2.71058

(3)Zhao Z, Meng M, Yao J, Zhou H, Chen Y, Liu J, et al. The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers. Cell Death & Disease 2023;10.1038/s41419-023-05802-3.

(4)Zhao Z, Xiang S, Qi J, Wei Y, Zhang M, Yao J, Zhang T, Meng M, Wang X, Zhou Q#. Correction of the tumor suppressor Salvador homolog-1 deficiency in tumors by lycorine as a new strategy in lung cancer therapy. Cell Death & Dis 2020; 11(5): 387

(5) Qi J, Meng M, Liu J, Song X, Chen Y, Liu Y, Li X, Zhou Z, Huang X, Wang X, Zhou Q#, Zhao Z#. Lycorine inhibits pancreatic cancer cell growth and neovascularization by inducing Notch1 degradation and downregulating key vasculogenic genes. Biochem Pharmacol 2023; 217: 115833.

(6) Liu X, Zhang L, Xu Z, Xiong X, Yu Y, Wu H, Qiao H, Zhong J, Zhao Z#, Dai J#, Suo G#. A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair. Acta Biomater 2022; 154: 385-400.

(7)Zhou H, Wang J, Wang X, Zhao Z#, Kuang Y#. SEL1L confers reduced EMT and drug resistance to breast cancer cells by promoting Shh degradation. iScience 2025; 10.1016/j.isci.2025.113876.

(8)一种肿瘤干细胞筛选和基于肿瘤干细胞的肿瘤类器官构建方法。索广力,赵喆,刘星志,ZL202210421807.7,2023.8. (已转化)

(9)一种循环肿瘤细胞捕获方法。索广力,熊璇,赵喆,刘星志, ZL202210375256.5,2024.6. (已转化)

(10)一种体外检测肿瘤起始细胞/干细胞频率的方法。索广力,赵喆,徐中娟,202610433268.7,2026.4. (已转化)